A Novel Histologic Scoring System to Evaluate Mucosal Biopsies From Patients With Eosinophilic Esophagitis
نویسندگان
چکیده
منابع مشابه
A novel histologic scoring system to evaluate mucosal biopsies from patients with eosinophilic esophagitis.
BACKGROUND & AIMS Eosinophilic esophagitis (EoE) is characterized by medically/surgically-resistant gastroesophageal reflux symptoms and dense squamous eosinophilia. Studies suggest that histologic assessment of esophageal eosinophilia alone cannot reliably separate patients with EoE from those with gastroesophageal reflux disease (GERD). Our goal was to develop an assay to identify EoE patient...
متن کاملOptimal Approach to Obtaining Mucosal Biopsies for Assessment of Eosinophilic Esophagitis and Lymphocytic Esophagitis
EoE is defined as a chronic, immune/antigen-mediated, esophageal disease characterized clinically by symptoms related to esophageal dysfunction and histologically by an eosinophilpredominant inflammation (≥15 eosinophils per high power field (hpf)) in the esophageal mucosa [1]. Endoscopic abnormalities in patients with EoE include esophageal rings, strictures, narrowcaliber esophagus, linear fu...
متن کاملCharacterizing the inflammatory response in esophageal mucosal biopsies in children with eosinophilic esophagitis
Eosinophilic esophagitis (EoE) is an emerging allergic, IgE- and non-IgE (Th2 cell)-mediated disease. There are major gaps in the understanding of the basic mechanisms that drive the persistence of EoE. We investigated whether esophageal biopsies from children with EoE demonstrate an inflammatory response that is distinct from normal controls. We prospectively enrolled 84 patients, of whom 77 w...
متن کاملMicroRNA Profiling in Mucosal Biopsies of Eosinophilic Esophagitis Patients Pre and Post Treatment with Steroids and Relationship with mRNA Targets
BACKGROUND The characterization of miRNAs and their target mRNAs involved in regulation of the immune process is an area of intense research and relatively little is known governing these processes in allergic inflammation. Here we present novel findings defining the miRNA and mRNA transcriptome in eosinophilic esophagitis (EoE), an increasing recognized allergic disorder. METHODS Esophageal ...
متن کاملCorrelation of increased PARP14 and CCL26 expression in biopsies from children with eosinophilic esophagitis.
Purna Krishnamurthy, MSa, Joseph D. Sherrill, PhDb, Kalyan Parashette, MDa, Shreevrat Goenka, PhDa, Marc E. Rothenberg, MD, PhDb, Sandeep Gupta, MDa, and Mark H. Kaplan, PhDa Mark H. Kaplan: [email protected] aDepartment of Pediatrics, Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Ind bDivision of Allergy and Immunology, ...
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ژورنال
عنوان ژورنال: Clinical Gastroenterology and Hepatology
سال: 2009
ISSN: 1542-3565
DOI: 10.1016/j.cgh.2009.03.022